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The genes which encode these osmolytes are called osmoregulation (osm) genes. We have now found that the osmoregulation genes are activated at the level of transcription. The most active osmoregulation genes, known as osmoregB and osmoregD, were cloned and found to be activators of transcription of the osmAB promoter. They were also found to increase the amount of osmolyte synthesized in vivo, thereby increasing the cell's tolerance to hypertonicity. The osmoregulation genes do not act by directly affecting DNA, but they are activated by a DNA-binding protein. We have identified the osmoregulation proteins and have found that they are high molecular weight proteins. They have specific binding sites at the osmoregB and osmoregD promoters, which provide a basis for a physical model of the osmoregulation proteins. The osmoregulation proteins interact in vivo and in vitro with the osmoregB and osmoregD promoters and to repress the expression of osmoregulation genes. 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Antidote The Antidote application gives you back the control over the notifications that you missed. It also gives you more control over the application as it can allow you to set a specific application as the default one. Mei Ears Mei Ears is an application for making custom iTunes playlists. The software will generate playlists based on your song library and gives you the option to create playlists based on the artists or the songs you listen to the most. Mocha Options If you want to have as much control as possible over the options that you want when using the Mac’s built-in calculator, the Mocha Options application will be useful. The software allows you to adjust the number of decimal places you want to see when you enter a calculation, plus, you can define the units in which you want to calculate, among other features. 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